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Activated by the antibiotic rifampicin and many plant metabolites, including hyperforin, guggulipid, colupulone, and isoflavones. Response to distinct ligands is species-specific. Activated by By natural means transpiring steroids, including pregnenolone and progesterone. Binds into a response factor while in the promoters on the CYP3A4 and ABCB1/M